The peptide designated hCDR1 was shown to mitigate the serological and clinical manifestations in both the spontaneous and induced models of SLE, to reduce the secretion and expression of the pathogenic cytokines interferon-gamma, interleukin-10, IL-1β and tumor necrosis factor-alpha and to up-regulate the immunosup-pressive cytokine transforming growth factor-beta. As a potential candidate for the specific treatment of SLE patients, we have designed and synthesized a peptide that is based on the sequence of the complementarity-determining region 1 of a human monoclonal anti-DNA autoantibody. In addition, we have previously established a model of experimentally induced SLE in various mouse strains. ![]() ![]() ![]() Several strains of mice that spontaneously develop a lupus-like disease were reported, of which the (NZBxNZW)F1 female mice are the most widely used. 40 Systemic lupus erythematosus is an autoimmune disease that is characterized by the production of antibodies against nuclear antigens and by damage to multiple organs.
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